MicroDiscovery GmbH, Berlin, Germany
Description of organisation
MicroDiscovery is an SME with excellent experience in the integrative analysis of genomic and proteomic data, and provides quality-assured bioinformatics solutions in the fields of innovative diagnostics, biomedical research, personalized medicine and systems biology. The portfolio includes bio-statistical data analysis and data management. Efficient proprietary algorithms are the basis for customer specific software development for In-vitro diagnostics and biomedical technology. Areas of application are the analysis of molecular and high-throughput data as well as image analyses and medical device control. Solutions can be developed as CE certified, FDA compliant (21 CRF part 11) and ISO 62304 compliant. We offer service and support in bioinformatics and biostatistics. We have experience in design, realization and evaluation of preclinical and clinical studies to find and validate biomarkers. This also includes the implementation of dedicated algorithms. In the fields of Genomics, Proteomics and Metabolomics we provide data integration, database development and data mining.
Previous experience
MicroDiscovery was coordinator of the international project SysProt (EC), and bioinformatics coordinator in cNEUPro (EC). In the international medical systems biology project SYSTHER (BMBF) MicroDiscovery is responsible for data analysis and data base development. In the multi-centre national projects ColoNet (BMBF) and PainSwitches (BMBF) was responsible for data analysis and data management.
Profile of staff members
Dr. Arif Malik is in charge of the company’s strategic direction and is responsible for Business Development. Prior to founding MicroDiscovery he worked as a bioinformatics scientist at Benjamin Franklin University Clinic and Max Planck Institute for Molecular Genetics in Berlin. Dr. Malik holds master degrees in computer science as well as biology and obtained a PhD in biology from the Free University of Berlin.
Dr. Dieter Beule leads the MicroDiscovery teams in software development and bioinformatics services. As an expert in quality management for medical software products, he monitors the advancement of the company. Dr. Beule studied physics in Freiburg, Sussex and Berlin and obtained his PhD from the Humboldt University in Berlin.
Dr. Johannes Schuchhardt is in charge of MicroDiscovery’s research activities and is coordinator of several international research projects funded by the Federal Ministry of Education and Research. He holds a PhD in Physics from the University of Kiel and is author of over 30 scientific publications in peer reviewed journals.
Webpage
Five recent publications relevant to the project
1) Schwanhäusser et al. Global quantification of mammalian gene expression control. Nature 2011, 473(7347):337-42.
2) Bauer et al. Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset. Methods Mol Biol. 2011, 696:341-52.
3) Gurumurthy et al. A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection. Sci Signal. 2010, 3(113):ra21.
4) Schmitt et al .The action of key factors in protein evolution at high temporal resolution. PLoS ONE. 2009, 4(3):e4821. Epub 2009 Mar 12.
5) Schuchhardt et al. BrainProfileDB - a platform for integration of functional genomics data. Proteomics 2008, 8(6):1162-1164.